During her Twelve Days of Giveaways promotion, audience members receive roughly $3,000 worth of prizes on each of twelve episodes. The program often features audience participation games where prizes are awarded. The program combines comedy, celebrity, musical guests, and human-interest stories. New episodes with guest hosts, clip shows hosted by DeGeneres and more, and repeats aired on stations across the United States until September 9, after which most stations (including NBC O&O) began occupying the show's time slot with new newscasts or syndication programs such as The Kelly Clarkson Show. The final episode aired on May 26, 2022, as previously announced on March 17, 2022. On May 12, 2021, DeGeneres announced that the nineteenth season would be her last, which premiered on September 13, 2021. The eighteenth season premiered on September 21, 2020.

On May 21, 2019, DeGeneres announced she had signed for three more years, renewing the show through 2022. The show also won 17 People's Choice Awards. The show received 171 Daytime Emmy Award nominations and won 61 Daytime Emmy Awards as of 2021, including four for Outstanding Talk Show and seven for Outstanding Talk Show Entertainment, making 11 total awards and surpassing the record held by The Oprah Winfrey Show, which won nine as Outstanding Talk Show before it was divided into two categories (Informative and Entertainment) in 2008.

Since the beginning of the sixth season, The Ellen DeGeneres Show has been broadcast in high definition. From season 6 onwards, the show moved to being taped at Stage 1 on the nearby Warner Bros. For its first five seasons, the show was taped in Studio 11 at NBC Studios in Burbank, California. The majority of stations owned by NBC Owned Television Stations, along with Hearst Television and Tegna, served as the program's largest affiliate base. The Ellen DeGeneres Show (stylized as ellen often shortened to Ellen or The Ellen Show) is an American daytime television variety comedy talk show created and hosted by its namesake Ellen DeGeneres that aired for 19 seasons from Septemto in syndication and was produced by Telepictures.

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